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. 2001 Nov;158(11):1920-2.
doi: 10.1176/appi.ajp.158.11.1920.

Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation

R A Lanius  1 , P C Williamson, M Densmore, K Boksman, M A Gupta, R W Neufeld, J S Gati, R S Menon
Affiliations

Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation

R A Lanius et al. Am J Psychiatry. 2001 Nov.

Abstract

Objective: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD.

Method: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength.

Results: PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects.

Conclusions: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

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