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. 2001 Nov;313(1-2):139-42.
doi: 10.1016/s0009-8981(01)00665-9.

About the possible origin and mechanism of circulating DNA apoptosis and active DNA release

M Stroun  1 , J Lyautey, C Lederrey, A Olson-Sand, P Anker
Affiliations

About the possible origin and mechanism of circulating DNA apoptosis and active DNA release

M Stroun et al. Clin Chim Acta. 2001 Nov.

Abstract

Background: In addition to cell lysis, apoptosis has been advanced as the origin of circulating DNA on the basis of several observations. Plasma or serum DNA often presents a ladder pattern reminiscent of that displayed by apoptotic cells when subjected to electrophoresis. However, the phenomenon of active release of DNA from cells might also be expected to result in a ladder pattern on electrophoresis. Non-dividing cells, such as lymphocytes, frog auricles and cultured cell lines including HL-60, spontaneously release a nucleoprotein complex within a homeostatic system in which newly synthesized DNA is preferentially released.

Conclusion: In relation to DNA synthesis, the phenomenon of extracellular DNA in different culture conditions favors apoptosis or spontaneous active DNA release.

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