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. 2001 Nov;108(9):1247-52.

doi: 10.1172/JCI14257.

Autoimmune type 1 diabetes: resolved and unresolved issues

A L Notkins¹, A Lernmark

Affiliations

Affiliation

¹ Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4322, USA. anotkins@dir.nidcr.nih.gov

PMID: 11696564
PMCID: PMC209446
DOI: 10.1172/JCI14257

Autoimmune type 1 diabetes: resolved and unresolved issues

A L Notkins et al. J Clin Invest. 2001 Nov.

. 2001 Nov;108(9):1247-52.

doi: 10.1172/JCI14257.

Authors

A L Notkins¹, A Lernmark

Affiliation

¹ Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4322, USA. anotkins@dir.nidcr.nih.gov

PMID: 11696564
PMCID: PMC209446
DOI: 10.1172/JCI14257

No abstract available

PubMed Disclaimer

Figures

Figure 1
Inflammatory infiltrate of mononuclear cells in an islet from a 2-year-old patient with type 1 diabetes of short duration. Mononuclear cells in and around islets are shown by yellow arrows. This patient was reported by Willy Gepts in his original contribution on insulitis in 1965 (45). The photomicrograph comes from the collection of W. Gepts and was kindly provided by Danny Pipeleers.

Figure 2
Diagrammatic representation of the effect of multiple autoantibodies (GAD65, IA-2, or insulin) on the risk of developing type 1 diabetes. Percent diabetes represents an approximation from several longitudinal studies on first-degree relatives of type 1 diabetes patients.

See this image and copyright information in PMC

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References

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