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. 2001 Oct 26;430(1):143-5.
doi: 10.1016/s0014-2999(01)01358-9.

Cocaine withdrawal in Planaria

R B Raffa  1 , J M Valdez
Affiliations

Cocaine withdrawal in Planaria

R B Raffa et al. Eur J Pharmacol. .

Abstract

Cocaine-exposed planarians displayed abstinence-induced withdrawal behavior when placed into cocaine-free, but not cocaine-containing, water. The effect, manifested and quantified using a new spontaneous locomotor velocity metric, was dose-dependently related to cocaine exposure (8x10(-9) to 8x10(-5) M). Ultraviolet light (254 nm=7.83x10(-19) J), which was previously shown to interfere with drug-receptor interactions in Planaria, enhanced the abstinence-induced decreased locomotor velocity.

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