Response adaptation of medial olivocochlear neurons is minimal

Abstract

Response adaptation is a general characteristic of neurons. A number of studies have investigated the adaptation characteristics of auditory-nerve fibers, which send information to the brain about sound stimuli. However, there have been no previous adaptation studies of olivocochlear neurons, which provide efferent fibers to hair cells and auditory nerve dendrites in the auditory periphery. To study adaptation in efferent fibers, responses of single olivocochlear neurons were recorded to characteristic-frequency tones and noise, using anesthetized guinea pigs. To measure short-term adaptation, stimuli of 500 ms duration were presented, and the responses were displayed as peristimulus time histograms. These histograms showed regular peaks, indicating a "chopping" pattern of response. The rate during each chopping period as well as the general trend of the histogram could be well fit by an equation that expresses the firing rate as a sum of 1) a short-term adaptive rate that decays exponentially with time and 2) a constant steady-state rate. For the adaptation in medial olivocochlear (MOC) neurons, the average exponential time constant was 47 ms, which is roughly similar to that for short-term adaptation in auditory-nerve fibers. The amount of adaptation (expressed as a percentage decrease of onset firing rate), however, was substantially less in MOC neurons (average 31%) than in auditory-nerve fibers (average 63%). To test for adaptation over longer periods, we used noise and tones of 10 s duration. After the short-term adaptation, the responses of MOC neurons were almost completely sustained (average long-term adaptation 3%). However, in the same preparations, significant long-term adaptation was present in auditory-nerve fibers. These results indicate that the MOC response adaptation is minimal compared with that of auditory-nerve fibers. Such sustained responses may enable the MOC system to produce sustained effects in the periphery, supporting a role for this efferent system during ongoing stimuli of long duration.