Hypercoagulability syndromes
- PMID: 11700155
- DOI: 10.1001/archinte.161.20.2433
Hypercoagulability syndromes
Abstract
Hypercoagulability can be defined as the tendency to have thrombosis as a result of certain inherited and/or acquired molecular defects. Clinical manifestations of hypercoagulability can be devastating and even lethal. In the past 20 years, the origin of most of these diverse hypercoagulability syndromes has been elucidated. Currently, hypercoagulability disorders can be correctly diagnosed in approximately 80% to 90% of patients. Defining the cause of hypercoagulability may determine the type and duration of treatment for the associated thrombosis. The discovery of an occult carcinoma allows for the possibility of early and possibly curative treatment. Finding a genetic defect in coagulation allows for testing of asymptomatic family members as well. The purpose of this review is to provide internists with a logical approach to the identification and treatment of hypercoagulability syndromes.
Comment in
-
The clot thickens! In thin air.Arch Intern Med. 2002 Aug 12-26;162(15):1783. doi: 10.1001/archinte.162.15.1783-a. Arch Intern Med. 2002. PMID: 12153391 No abstract available.
-
Antiphospholipid antibodies.Arch Intern Med. 2002 Aug 12-26;162(15):1783-4; author reply 1786-7. doi: 10.1001/archinte.162.15.1783-b. Arch Intern Med. 2002. PMID: 12153392 No abstract available.
-
Genetic hypercoagulability syndromes: does testing really matter?Arch Intern Med. 2002 Aug 12-26;162(15):1784-5; author reply 1786-7. doi: 10.1001/archinte.162.15.1784. Arch Intern Med. 2002. PMID: 12153393 No abstract available.
-
Hypercoagulable disorders.Arch Intern Med. 2002 Aug 12-26;162(15):1785-6; author reply 1786-7. doi: 10.1001/archinte.162.15.1785. Arch Intern Med. 2002. PMID: 12153394 No abstract available.
Similar articles
-
[Evaluation of hemostasis in venous thromboembolism pathology].Ann Biol Clin (Paris). 1998 Jan-Feb;56(1):49-56. Ann Biol Clin (Paris). 1998. PMID: 9754222 Review. French.
-
[Thrombosis and cardiovascular diseases].Pediatr Med Chir. 2003 Sep-Oct;25(5):329-37. Pediatr Med Chir. 2003. PMID: 15058830 Review. Italian.
-
Evaluation of thrombotic children with malignancy.Ann Hematol. 2005 Jun;84(6):395-9. doi: 10.1007/s00277-005-1004-x. Epub 2005 Feb 26. Ann Hematol. 2005. PMID: 15735962
-
Testing for genetic predisposition to venous thrombosis.MLO Med Lab Obs. 2002 Jan;34(1):8-13; quiz 20-1. MLO Med Lab Obs. 2002. PMID: 11828956 Review. No abstract available.
-
Laboratory investigation of hypercoagulability.Semin Thromb Hemost. 1998;24(2):111-26. doi: 10.1055/s-2007-995830. Semin Thromb Hemost. 1998. PMID: 9579632 Review.
Cited by
-
Retinal Vein Occlusion Amongst People Vaccinated by mRNA- and Viral Vector- COVID-19 Vaccines: A Systematic Review.Clin Ophthalmol. 2023 Sep 28;17:2825-2842. doi: 10.2147/OPTH.S426428. eCollection 2023. Clin Ophthalmol. 2023. PMID: 37794952 Free PMC article. Review.
-
Clinical Significance of Hyperhomocysteinemia in Free Flap Failure: A Case Report.Arch Plast Surg. 2024 Aug 6;52(3):197-201. doi: 10.1055/a-2336-0262. eCollection 2025 May. Arch Plast Surg. 2024. PMID: 40386001 Free PMC article.
-
Lactoferrin and Activated Protein C: Potential Role in Prevention of Cancer Progression and Recurrence.Int J Mol Cell Med. 2023;12(1):86-99. doi: 10.22088/IJMCM.BUMS.12.1.86. Int J Mol Cell Med. 2023. PMID: 37942258 Free PMC article. Review.
-
Bilateral Central Retinal Vein Occlusion in Recurrent Frontal Lobe Tumor.Cureus. 2023 Jul 6;15(7):e41441. doi: 10.7759/cureus.41441. eCollection 2023 Jul. Cureus. 2023. PMID: 37546071 Free PMC article.
-
The impact of inherited thrombophilia on surgery: a factor to consider before transplantation?Mol Biol Rep. 2009 May;36(5):1041-51. doi: 10.1007/s11033-008-9278-4. Epub 2008 May 31. Mol Biol Rep. 2009. PMID: 18516702 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
