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Review
. 2001 Nov 12;161(20):2433-9.
doi: 10.1001/archinte.161.20.2433.

Hypercoagulability syndromes

R H Thomas  1
Affiliations
Review

Hypercoagulability syndromes

R H Thomas. Arch Intern Med. .

Abstract

Hypercoagulability can be defined as the tendency to have thrombosis as a result of certain inherited and/or acquired molecular defects. Clinical manifestations of hypercoagulability can be devastating and even lethal. In the past 20 years, the origin of most of these diverse hypercoagulability syndromes has been elucidated. Currently, hypercoagulability disorders can be correctly diagnosed in approximately 80% to 90% of patients. Defining the cause of hypercoagulability may determine the type and duration of treatment for the associated thrombosis. The discovery of an occult carcinoma allows for the possibility of early and possibly curative treatment. Finding a genetic defect in coagulation allows for testing of asymptomatic family members as well. The purpose of this review is to provide internists with a logical approach to the identification and treatment of hypercoagulability syndromes.

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Comment in

  • The clot thickens! In thin air.
    Kashyap AS, Kashyap S. Kashyap AS, et al. Arch Intern Med. 2002 Aug 12-26;162(15):1783. doi: 10.1001/archinte.162.15.1783-a. Arch Intern Med. 2002. PMID: 12153391 No abstract available.
  • Antiphospholipid antibodies.
    Moll S, Ortel TL. Moll S, et al. Arch Intern Med. 2002 Aug 12-26;162(15):1783-4; author reply 1786-7. doi: 10.1001/archinte.162.15.1783-b. Arch Intern Med. 2002. PMID: 12153392 No abstract available.
  • Genetic hypercoagulability syndromes: does testing really matter?
    Procopiou M. Procopiou M. Arch Intern Med. 2002 Aug 12-26;162(15):1784-5; author reply 1786-7. doi: 10.1001/archinte.162.15.1784. Arch Intern Med. 2002. PMID: 12153393 No abstract available.
  • Hypercoagulable disorders.
    Goichot B, Perrin AE. Goichot B, et al. Arch Intern Med. 2002 Aug 12-26;162(15):1785-6; author reply 1786-7. doi: 10.1001/archinte.162.15.1785. Arch Intern Med. 2002. PMID: 12153394 No abstract available.

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