doi: 10.1126/science.1064462.
Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes
Affiliations
- PMID: 11701932
- DOI: 10.1126/science.1064462
Item in Clipboard
Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes
Science.
.
Abstract
We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4+ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.
Similar articles
-
The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells.J Infect Dis. 2006 Dec 1;194(11):1609-16. doi: 10.1086/508896. Epub 2006 Oct 23. J Infect Dis. 2006. PMID: 17083048 Free PMC article.
-
CD4+ T-cell receptor V beta usage during the immune response to Schistosoma mansoni.Infect Immun. 1993 Dec;61(12):5381-3. doi: 10.1128/iai.61.12.5381-5383.1993. Infect Immun. 1993. PMID: 7901168 Free PMC article.
-
Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium.Parasitol Res. 2017 Nov;116(11):3175-3188. doi: 10.1007/s00436-017-5634-4. Epub 2017 Oct 12. Parasitol Res. 2017. PMID: 29026995 Free PMC article.
-
T Lymphocyte-Mediated Liver Immunopathology of Schistosomiasis.Front Immunol. 2020 Feb 18;11:61. doi: 10.3389/fimmu.2020.00061. eCollection 2020. Front Immunol. 2020. PMID: 32132991 Free PMC article. Review.
-
Th2 response polarization during infection with the helminth parasite Schistosoma mansoni.Immunol Rev. 2004 Oct;201:117-26. doi: 10.1111/j.0105-2896.2004.00187.x. Immunol Rev. 2004. PMID: 15361236 Review.
Cited by
-
Sex-inducing effects toward planarians widely present among parasitic flatworms.iScience. 2022 Dec 8;26(1):105776. doi: 10.1016/j.isci.2022.105776. eCollection 2023 Jan 20. iScience. 2022. PMID: 36594009 Free PMC article.
-
A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.PLoS Negl Trop Dis. 2019 Jan 17;13(1):e0007070. doi: 10.1371/journal.pntd.0007070. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30653492 Free PMC article.
-
Co-infection with Schistosoma mansoni and Human Immunodeficiency Virus-1 (HIV-1) among residents of fishing villages of north-western Tanzania.Parasit Vectors. 2014 Dec 16;7:587. doi: 10.1186/s13071-014-0587-2. Parasit Vectors. 2014. PMID: 25511298 Free PMC article.
-
Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate.Nat Commun. 2021 Jan 20;12(1):485. doi: 10.1038/s41467-020-20794-w. Nat Commun. 2021. PMID: 33473133 Free PMC article.
-
The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells.J Infect Dis. 2006 Dec 1;194(11):1609-16. doi: 10.1086/508896. Epub 2006 Oct 23. J Infect Dis. 2006. PMID: 17083048 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
