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Review
. 2001 Nov;6(11):874-82.
doi: 10.1046/j.1365-3156.2001.00777.x.

Biochemical and molecular mechanisms of drug resistance in parasites

M Ouellette  1
Affiliations
Free article
Review

Biochemical and molecular mechanisms of drug resistance in parasites

M Ouellette. Trop Med Int Health. 2001 Nov.
Free article

Abstract

Drug resistance is complicating the treatment of parasitic diseases. We review here the basic mechanisms of parasite resistance in malaria, sleeping sickness, leishmaniasis and common helminthiases. Parasites resort to multiple biochemical means to achieve resistance and we have begun to isolate and characterize the genes/proteins implicated in resistance. Understanding drug resistance is essential for the control of parasitic diseases.

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