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. 2001 Nov 13;57(9):1642-9.
doi: 10.1212/wnl.57.9.1642.

Risk of epilepsy in offspring of affected women: association with maternal spontaneous abortion

N Schupf  1 , R Ottman
Affiliations

Risk of epilepsy in offspring of affected women: association with maternal spontaneous abortion

N Schupf et al. Neurology. .

Abstract

Background: Previously, the authors found that risk of spontaneous abortion was increased in the pregnancies of women with epilepsy compared with their same-sex siblings, which could have implications for risk of epilepsy in their offspring. An association between a history of spontaneous abortion in the mother and risk of epilepsy in her live-born offspring may arise through selective loss of fetuses with a genetic susceptibility to epilepsy or through intrauterine environmental factors that may predispose the mother to a spontaneous abortion and to epilepsy in her live-born children.

Method: The authors examined the relation of a history of spontaneous abortion to the risk of idiopathic or cryptogenic epilepsy in 791 live-born offspring of 385 women with cryptogenic localization-related epilepsy (probands) ascertained from voluntary organizations. A semistructured telephone interview with probands and additional family informants, supplemented by medical record review, was used to obtain information on seizures and other risk factors in probands and relatives.

Results: Live-born offspring of women with a history of spontaneous abortion were four or five times as likely to develop epilepsy as were children of women without (12.8% versus 4.7%; rate ratio = 4.6, 95% CI: 2.3-9.0). Cumulative incidence of epilepsy was 21.9% in offspring of women with a history of spontaneous abortion and a family history of epilepsy, compared with 4.7% in offspring of women with neither risk factor.

Conclusions: These results suggest that a history of spontaneous abortion is associated with increased risk of epilepsy in live-born offspring and may be a marker for genetic susceptibility for epilepsy in the mother.

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Figures

Figure
Figure
Cumulative incidence of idiopathic or cryptogenic epilepsy to age 25 in offspring of women with cryptogenic epilepsy with and without a history of spontaneous abortion. Solid line = offspring of women with a history of spontaneous abortion. Dashed line = offspring of women without a history of spontaneous abortion.
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