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Clinical Trial
. 2001 Nov 13;57(9):1717-9.
doi: 10.1212/wnl.57.9.1717.

Treatment of idiopathic restless legs syndrome (RLS) with gabapentin

S Happe  1 , G Klösch, B Saletu, J Zeitlhofer
Affiliations
Clinical Trial

Treatment of idiopathic restless legs syndrome (RLS) with gabapentin

S Happe et al. Neurology. .

Abstract

Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly. Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS.

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