The relentless effects of the aging process on protein turnover

Abstract

Protein turnover encompasses the processes of protein synthesis and protein degradation. Because of the essential structural and catalytic roles that proteins play in the cell, there has been a long-standing interest in the effects of aging on protein turnover. The purpose of this review is to incorporate relevant data published since the area was previously reviewed and to provide an update on the status of research with particular attention to the pathways of protein degradation.