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. 1975 Aug 2;3(5978):274-5.
doi: 10.1136/bmj.3.5978.274.

An abnormality of oestrogen feedback in amenorrhoea-galactorrhoea

M R Glass, R W Shaw, W R Butt, R L Edwards, D R London

An abnormality of oestrogen feedback in amenorrhoea-galactorrhoea

M R Glass et al. Br Med J. .

Abstract

Fourteen patients with amenorrhoea and hyperprolactin-anemia but no evidence of pituitary tumours were each given an intramuscular injection of 1 mg oestradiol benzoate. Thirteen patients failed to release luteinizing hormone in response to the oestrogen. This hypothalamic abnormality may help to explain the menstrual disturbances in subjects with hyperprolactinaemia.

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