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. 2001 Oct 29;12(15):3371-3.
doi: 10.1097/00001756-200110290-00044.

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

O A Andreassen  1 , R J Ferrante, A Dedeoglu, M F Beal
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Lipoic acid improves survival in transgenic mouse models of Huntington's disease

O A Andreassen et al. Neuroreport. .

Abstract

There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenyibutyinitrone (S-PBN) and alpha-lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha-Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha-lipoic acid might have beneficial effects in HD patients.

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