Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Jul-Aug;21(4B):3097-9.

Large loop excision of the transformation zone for treating cervical intraepithelial neoplasia: a 12-year experience

E Paraskevaidis  1 , G Koliopoulos, V Malamou-Mitsi, K Zikopoulos, M Paschopoulos, L Pappa, N J Agnantis, D E Loli
Affiliations
  • PMID: 11712817

Large loop excision of the transformation zone for treating cervical intraepithelial neoplasia: a 12-year experience

E Paraskevaidis et al. Anticancer Res. 2001 Jul-Aug.

Abstract

Background: Although the existing evidence suggests that there is no obviously superior conservative method for treating cervical intraepithelial neoplasia (CIN), one of the most widely used is the large loop excision of the transformation zone (LLETZ).

Materials and methods: A total of 897 women who were treated with LLETZ at our colposcopy clinic from 1989 to 2000 were retrospectively studied.

Results: Forty women did not have significant cervical pathology (4.5% over-treatment rate). Clear margins of excision were obtained in 748 (88.5%) of the 845 cases of CIN or microinvasive cancers. Treatment failure rates were 4.7% for clear margins and 26.8% for involved or uncertain.

Conclusion: LLETZ is a fast and reliable method of treating CIN and microinvasive carcinoma. Generalized cauterization of the resulting crater should be avoided and satellite HPV lesions ablated. Involved margins have a higher treatmentfailure rate, therefore a larger excision is recommended as cervical craters regenerate. Treatment in pregnant women can be delayed until postpartum provided they have adequate surveillance during pregnancy.

PubMed Disclaimer