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Review
. 2001 Dec;21(24):8247-54.
doi: 10.1128/MCB.21.24.8247-8254.2001.

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

A Krueger  1 , S Baumann, P H Krammer, S Kirchhoff
Affiliations
Review

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

A Krueger et al. Mol Cell Biol. 2001 Dec.
No abstract available

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Figures

FIG. 1
FIG. 1
Structural similarities between caspase 8 and FLIP. For details, refer to the text.
FIG. 2
FIG. 2
Model for c-FLIP-mediated inhibition of procaspase 8 processing at the DISC. (A) The CD95 DISC. For details, refer to the text. (B to D) Depending on the ratio of procaspase 8 and c-FLIP proteins at the DISC (A, grey box), different products are released from the DISC upon receptor triggering. (B) Small amounts of c-FLIP proteins allow processing of procaspase 8, leading to the formation of the active caspase 8 heterotetramer composed of the p18 and p10 subunits. (C) In the presence of large amounts of c-FLIPL procaspase 8 is recruited into the DISC, and cleavage is blocked after generation of the p43 cleavage products of both caspase 8 and c-FLIPL. (D) In the presence of large amounts of c-FLIPS procaspase 8 is recruited into the DISC but remains unprocessed. In each case, modulation of caspase 8 cleavage renders cells resistant to CD95-mediated cell death.
FIG. 2
FIG. 2
Model for c-FLIP-mediated inhibition of procaspase 8 processing at the DISC. (A) The CD95 DISC. For details, refer to the text. (B to D) Depending on the ratio of procaspase 8 and c-FLIP proteins at the DISC (A, grey box), different products are released from the DISC upon receptor triggering. (B) Small amounts of c-FLIP proteins allow processing of procaspase 8, leading to the formation of the active caspase 8 heterotetramer composed of the p18 and p10 subunits. (C) In the presence of large amounts of c-FLIPL procaspase 8 is recruited into the DISC, and cleavage is blocked after generation of the p43 cleavage products of both caspase 8 and c-FLIPL. (D) In the presence of large amounts of c-FLIPS procaspase 8 is recruited into the DISC but remains unprocessed. In each case, modulation of caspase 8 cleavage renders cells resistant to CD95-mediated cell death.
See this image and copyright information in PMC

References

    1. Aggarwal S, Gupta A, Nagata S, Gupta S. Programmed cell death (apoptosis) in cord blood lymphocytes. J Clin Immunol. 1997;17:63–73. - PubMed
    1. Alderson M R, Tough T W, Davis-Smith T, Braddy S, Falk B, Schooley K A, Goodwin R G, Smith C A, Ramsdell F, Lynch D H. Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med. 1995;181:71–77. - PMC - PubMed
    1. Algeciras-Schimnich A, Griffith T S, Lynch D H, Paya C V. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. J Immunol. 1999;162:5205–5211. - PubMed
    1. Aoki K, Kurooka M, Chen J J, Petryniak J, Nabel E G, Nabel G J. Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat Immunol. 2001;2:333–337. - PubMed
    1. Aoudjit F, Vuori K. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol. 2001;152:633–643. - PMC - PubMed

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