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. 2001 Nov;3(11):950-7.
doi: 10.1038/ncb1101-950.

Timing of cyclin D1 expression within G1 phase is controlled by Rho

C F Welsh  1 , K Roovers, J Villanueva, Y Liu, M A Schwartz, R K Assoian
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Timing of cyclin D1 expression within G1 phase is controlled by Rho

C F Welsh et al. Nat Cell Biol. 2001 Nov.

Erratum in

  • Nat Cell Biol. 2009 Dec;11(12):1496

Abstract

The expression of cyclin D1 in mid-G1 phase is associated with sustained ERK activity, and we show here that Rho is required for the sustained ERK signal. However, we also report that Rho inhibits an alternative Rac/Cdc42-dependent pathway, which results in a strikingly early G1-phase expression of cyclin D1. Thus, cyclin D1 is induced in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than Rac and Cdc42. Our results show that Rho is crucial for maintaining the correct timing of cyclin D1 expression in G1 phase and describe a new role for cytoskeletal integrity in the regulation of cell cycle progression.

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Comment in

  • A family outing: small GTPases cyclin' through G1.
    Coleman ML, Marshall CJ. Coleman ML, et al. Nat Cell Biol. 2001 Nov;3(11):E250-1. doi: 10.1038/ncb1101-e250. Nat Cell Biol. 2001. PMID: 11715034 No abstract available.
  • Findings of misconduct in science.
    [No authors listed] [No authors listed] NIH Guide Grants Contracts (Bethesda). 2007 Jul 20:NOT-OD-07-075. NIH Guide Grants Contracts (Bethesda). 2007. PMID: 17647301 Free PMC article. No abstract available.
  • Findings of Misconduct in Science.
    [No authors listed] [No authors listed] Fed Regist. 2007 Jul 16;72(135):38836-38837. Fed Regist. 2007. PMID: 27737163 Free PMC article. No abstract available.

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