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Review
. 2001 Nov 20;98(24):13476-8.
doi: 10.1073/pnas.251530798.

Glucose and cAMP: adversaries in the regulation of hepatic gene expression

H C Towle  1
Affiliations
Review

Glucose and cAMP: adversaries in the regulation of hepatic gene expression

H C Towle. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic of the roles of ChREBP and SREBP in regulation of lipogenic enzyme gene transcription. Most lipogenic enzyme genes (e.g., fatty acid synthase) have response elements for binding ChREBP (ChoRE) and SREBP (SRE). These two factors work synergistically to induce transcription of the lipogenic enzyme genes in the presence of glucose and insulin. Glucagon, through its intracellular mediator cAMP, and polyunsaturated fatty acids (PUFAs) act to inhibit the activity of ChREBP and SREBP, respectively. In this manner, the output of lipogenic enzyme gene production is integrated to multiple nutrient and hormonal signals.
See this image and copyright information in PMC

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