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Review
. 2001 Nov 16;107(4):415-8.
doi: 10.1016/s0092-8674(01)00581-5.

A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

K Nishikura  1
Affiliations
Free article
Review

A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

K Nishikura. Cell. .
Free article

Abstract

One of the many intriguing features of gene silencing by RNA interference is the apparent catalytic nature of the phenomenon. New biochemical and genetic evidence now shows that an RNA-directed RNA polymerase chain reaction, primed by siRNA, amplifies the interference caused by a small amount of "trigger" dsRNA.

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