Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Nov 24;323(7323):1228-31.
doi: 10.1136/bmj.323.7323.1228.

Recent advances: Psychiatry

D Lyons  1 , D M McLoughlin
Affiliations
Review

Recent advances: Psychiatry

D Lyons et al. BMJ. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Transcranial magnetic stimulation is based on the principle that an electric current passing through a flat handheld insulated coil placed tangentially on the scalp generates a magnetic field. This can be targeted to a selected scalp area (∼cm2) and induces a secondary electrical field in the underlying cortex, causing neuronal depolarisation. Patients can be given a single brief magnetic pulse or a series of pulses (repetitive transcranial magnetic stimulation). Excitability of neurones is enhanced by fast repetitive transcranial magnetic stimulation (usually 5-20 Hz) but inhibited by slow repetitive transcranial magnetic stimulation (<1 Hz). The effect depends on the site stimulated
Figure 2
Figure 2
Proteolytic cleavage of amyloid precursor protein by β site amyloid precursor protein cleavage enzyme (BACE) and presenilin-1, a candidate protein for γ-secretase. Inhibition of β or γ cleavage reduces production of β amyloid, which has been linked to Alzheimer's disease. D denotes conserved aspartic acid residues that are candidate active sites for cleavage
See this image and copyright information in PMC

References

    1. World Health Organization. The world health report 2000—health systems: improving performance. Geneva: WHO; 2000.
    1. Rosenfield S. Labelling mental illness: the effects of received services and perceived stigma on life satisfaction. American Sociological Review. 1997;62:660–672.
    1. Gureje O, Alem A. Mental health policy development in Africa. Bull World Health Org. 2000;78:475–482. - PMC - PubMed
    1. Crisp AH, Gelder MG, Rix S, Meltzer HI, Rowlands OJ. Stigmatisation of people with mental illnesses. Br J Psychiatry. 2000;177:4–7. - PubMed
    1. Byrne P. Stigma of mental illness and ways of diminishing it. Adv Psychiat Treat. 2000;6:65–72.

MeSH terms