Dopaminergic drugs antagonize the psychotomimetic effects of partial-agonist analgesics
- PMID: 1172254
- DOI: 10.1007/BF00421271
Dopaminergic drugs antagonize the psychotomimetic effects of partial-agonist analgesics
Abstract
The psychotomimetic actions of the partial-agonist analgesic drugs cyclazocine and levallophan have been demonstrated using a quantitative behavioural test in young rats which measures lateral head movements and pivoting on the hind paws. This drug induced behaviour is antagonized by low doses of the dopaminergic agonists apomorphine and piribedil, the dopamine releasing drug amphetamine, the dopamine reuptake blocking agent benztropine and by large doses of the dopamine precursor L-Dopa. Naloxone antagonize the behaviour, but only at one hundred times the analgesic antagonist dose. These results show that dopaminergic systems are implicated in the mechanism of action of partial-agonist induced psychotomimetic side effects.
Similar articles
-
Induction and reversal of dopamine dyskinesia in rat, cat, and monkey.Psychopharmacology Suppl. 1985;2:200-10. doi: 10.1007/978-3-642-70140-5_25. Psychopharmacology Suppl. 1985. PMID: 2987905
-
Influence of dopamine-like compounds on stereotypy and locomotor activity in atropinized rats.Arch Immunol Ther Exp (Warsz). 1975;23(6):753-61. Arch Immunol Ther Exp (Warsz). 1975. PMID: 1241267
-
Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments.Psychopharmacology (Berl). 1988;94(1):79-83. doi: 10.1007/BF00735885. Psychopharmacology (Berl). 1988. PMID: 3126531
-
Apomorphine and piribedil in rats: biochemical and pharmacologic studies.Adv Neurol. 1975;9:307-26. Adv Neurol. 1975. PMID: 1170716
-
Dopaminergic mechanisms and stereotyped behaviour in birds.Pharmacol Res Commun. 1979 Jul;11(7):555-70. doi: 10.1016/s0031-6989(79)80028-4. Pharmacol Res Commun. 1979. PMID: 116248 Review. No abstract available.
Cited by
-
Effects of acute administration of cyclazocine on the metabolism of biogenic amines in different regions of rat brain.Psychopharmacology (Berl). 1981;75(1):79-83. doi: 10.1007/BF00433507. Psychopharmacology (Berl). 1981. PMID: 6171003
-
Evidence for increased apomorphine-sensitive dopaminergic effects after acute treatment with morphine.Psychopharmacology (Berl). 1977 Jun 6;53(1):55-63. doi: 10.1007/BF00426694. Psychopharmacology (Berl). 1977. PMID: 407614 No abstract available.
-
Backward walking and circling: behavioural responses induced by drug treatments which cause simultaneous release of catecholamines and 5-hydroxytryptamine.Br J Pharmacol. 1979 Aug;66(4):573-9. doi: 10.1111/j.1476-5381.1979.tb13696.x. Br J Pharmacol. 1979. PMID: 465894 Free PMC article.
-
Behavioral effects of cyclazocine on rats assessed in the open field and residential maze.Psychopharmacology (Berl). 1984;84(3):323-30. doi: 10.1007/BF00555207. Psychopharmacology (Berl). 1984. PMID: 6440178