Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Nov 27;57(10):1763-6.
doi: 10.1212/wnl.57.10.1763.

The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type

G D Silverberg  1 , G Heit, S Huhn, R A Jaffe, S D Chang, H Bronte-Stewart, E Rubenstein, K Possin, T A Saul
Affiliations

The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type

G D Silverberg et al. Neurology. .

Abstract

Objective: To evaluate the production rate of CSF in patients with differing disease states.

Methods: The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven with dementia of the Alzheimer's type (AD) (aged 72 +/- 9 years, mean +/- SD). This method, based on the Masserman technique, employs ventricular rather than a lumbar access to the CSF space. Furthermore, the volume of CSF removed during the procedure is only 3 mL rather than 10 mL.

Results: These measurements indicate that the mean rate of CSF production in patients with PD under age 60 was 0.47 +/- 0.13 mL/minute, in patients with PD aged 60 or older the mean rate was 0.40 +/- 0.12 mL/minute, and in patients with AD the mean rate was 0.20 +/- 0.06 mL/minute.

Conclusion: These results indicate that the rate of CSF production in patients with PD is normal, and that the rate of CSF production in patients with AD is markedly reduced.

PubMed Disclaimer

Publication types