Intravenous valproate in status epilepticus

Abstract

Objective: To evaluate the role of intravenous valproate sodium (IV VPA) in the treatment of status epilepticus (SE).

Data sources: A literature search of the English language was performed (MEDLINE 1966-July 2000). Search terms included valproate, valproic acid, and status epilepticus. Bibliographies of articles chosen were reviewed to identify other possible sources.

Data synthesis: A review of the medical literature was conducted to evaluate the safety and efficacy of IV VPA in the treatment of SE.

Conclusions: Experience with IV VPA in the treatment of SE is too limited to recommend its use as a first-line agent. IV VPA may represent a third- or fourth-line option in cases of SE when other agents are ineffective or contraindicated.