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Review
. 2001 Nov 26;155(5):705-10.
doi: 10.1083/jcb.200107040. Epub 2001 Nov 26.

Evolutionary perspective on innate immune recognition

A Mushegian  1 , R Medzhitov
Affiliations
Review

Evolutionary perspective on innate immune recognition

A Mushegian et al. J Cell Biol. .

Abstract

Analysis of human and Drosophila genomes demonstrates an ancient origin of innate immunity and the diversity of the mechanisms of innate immune recognition.

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Figures

Figure 1.
Figure 1.
Fractions of human innate immunity proteins shared with completely sequenced genomes representing different evolutionary lineages. Sequences were decomposed into discrete globular domains using the local compositional complexity measures. The “orthologues” graph indicates which percentage of human/mammalian proteins have orthologues in a given lineage. The procedures for orthologue definition has been described (Snel et al., 1999; Tatusov et al., 2001). The “shuffled domains” graph indicates the fraction of human domains found in a given lineage in a nonorthologous arrangements. The “all shared domains” graph indicates all related domains in each lineage, that is, the sum of orthologues and shuffled domains. See http://www.jcb.org/cgi/content/full/jcb.200107040/DC1 for the complete listing of proteins and conserved domains.
See this image and copyright information in PMC

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