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Case Reports
. 2001 Dec;39(12):4420-5.
doi: 10.1128/JCM.39.12.4420-4425.2001.

Multidrug-resistant Trichosporon asahii infection of nongranulocytopenic patients in three intensive care units

D G Wolf  1 , R Falk, M Hacham, B Theelen, T Boekhout, G Scorzetti, M Shapiro, C Block, I F Salkin, I Polacheck
Affiliations
Case Reports

Multidrug-resistant Trichosporon asahii infection of nongranulocytopenic patients in three intensive care units

D G Wolf et al. J Clin Microbiol. 2001 Dec.

Abstract

Trichosporon asahii (Trichosporon beigelii) infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. We report on the recent recovery of T. asahii isolates with reduced susceptibility in vitro to amphotericin B (AMB), flucytosine, and azoles from six nongranulocytopenic patients who exhibited risk factors and who developed either superficial infections (four individuals) or invasive infections (two individuals) while in intensive care units. The latter two patients responded clinically and microbiologically to AMB treatment. All six isolates were closely related according to random amplified polymorphic DNA studies and showed 71% similarity by amplified fragment length polymorphism analysis, suggesting a common nosocomial origin. We also review the literature pertaining to T. asahii infections and discuss the salient characteristics of this fungus and recent taxonomic proposals for the genus.

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Figures

FIG. 1
FIG. 1
Clustering of Trichosporon obtained with primers with the adenosine extension. The clustering was obtained by the unweighted pair group method using arithmetic averages and shows the relationships between isolates of T. asahii on the basis of AFLP analysis with selective primer EcoRI-A[FAM] in combination with primer MseI-G.
See this image and copyright information in PMC

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