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. 2001 Dec;2(12):1109-16.
doi: 10.1038/ni739.

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

J J McIntire  1 , S E Umetsu, O Akbari, M Potter, V K Kuchroo, G S Barsh, G J Freeman, D T Umetsu, R H DeKruyff
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Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

J J McIntire et al. Nat Immunol. 2001 Dec.

Abstract

To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy.

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