Review
doi: 10.1016/s0165-6147(00)01824-1.
Universality of receptor channel responses
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- PMID: 11730975
- DOI: 10.1016/s0165-6147(00)01824-1
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Review
Universality of receptor channel responses
Trends Pharmacol Sci.
2001 Dec.
Abstract
Rate parameters estimated for neurotransmitter-gated receptor channel opening and receptor desensitization are classified according to their dependence on the temporal resolution of the techniques applied in the measurements. Because allosteric proteins constituting receptor channels impose restrictions on the types of model suitable to describe the dynamic response of channels to neurotransmitters, Markovian, non-linear or fractal dynamic models and their possible extension to receptor channel response in excitable membranes are discussed.
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