RNA targets of the fragile X protein
- PMID: 11733054
- DOI: 10.1016/s0092-8674(01)00590-6
RNA targets of the fragile X protein
Abstract
Three papers published recently in Cell bring the power of human genetics, Drosophila genetics, and genomics to bear on the understanding of fragile X syndrome. They provide further support for the importance of local protein synthesis within a neuron as a determinant of proper synaptogenesis and the development of cognitive abilities.
Comment on
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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.Cell. 2001 Nov 16;107(4):477-87. doi: 10.1016/s0092-8674(01)00568-2. Cell. 2001. PMID: 11719188
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Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.Cell. 2001 Nov 16;107(4):489-99. doi: 10.1016/s0092-8674(01)00566-9. Cell. 2001. PMID: 11719189
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Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function.Cell. 2001 Nov 30;107(5):591-603. doi: 10.1016/s0092-8674(01)00589-x. Cell. 2001. PMID: 11733059
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