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Comment
. 2001 Dec;108(11):1575-6.
doi: 10.1172/JCI14454.

A kinase in the life of the beta cell

D Accili  1
Affiliations
Comment

A kinase in the life of the beta cell

D Accili. J Clin Invest. 2001 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Regulation of β cell function by tyrosine kinase pathways. There is evidence for participation of tyrosine kinase signaling in different β cell functions. Interestingly, activation of PI 3-kinase is thought to be important for cell size control, neogenesis and proliferation, apoptosis, and insulin synthesis or secretion. However, the pathways activated by PI 3-kinase appear to diverge, with Akt contributing to growth and size control but not to insulin secretion. It is unclear how PI 3-kinase signaling is linked to insulin synthesis or secretion, since insulin regulation is unaffected by loss of p70s6k1. On the other hand, phosphorylation of eIF2α on Ser51 by the kinase gene Perk is thought to play an important role in insulin mRNA translation.
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