Review
doi: 10.1038/35103104.
The role of Fas ligand in immune privilege
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- PMID: 11733771
- DOI: 10.1038/35103104
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Review
The role of Fas ligand in immune privilege
Nat Rev Mol Cell Biol.
2001 Dec.
Abstract
Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.
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