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. 2001 Nov 24;358(9295):1782-3.
doi: 10.1016/S0140-6736(01)06809-X.

Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear

M A Nobbenhuis, T J Helmerhorst, A J van den Brule, L Rozendaal, F J Voorhorst, P D Bezemer, R H Verheijen, C J Meijer

Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear

M A Nobbenhuis et al. Lancet. .

Abstract

We studied the natural course of high-risk human papillomavirus (HPV) infection and cytological regression in women referred for colposcopy because of abnormal cervical smears. We found that high-risk HPV clearance preceded regression of cervical lesions by an average of 3 months. The cumulative 1-year rate of cytological regression was similar in women with mild and moderate dyskaryotic cervical smears. Thus, retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.

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