Residue levels of DDE and PCBs in the blood serum of women in the Port Said region of Egypt

Abstract

An investigation was conducted to detect residues of 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) and polychlorinated biphenyls (PCBs) in blood serum samples collected from a cohort of fasting females attending the health insurance outpatient clinic at Port Said between July 1999 and July 2000. Females involved in the study included 43 females diagnosed with invasive adenocarcinoma of the breast, 21 female suffering benign breast disease, and 11 normal healthy females. Serum was separated and its contents of DDE and PCBs were extracted and determined, using gas chromatography, equipped with electron capture detector. Mean residues of DDE detected in the three examined groups of females were 41+/-5.2, 48+/-6.2 and 31+/-2.5ng/g for breast cancer cases, benign breast disease cases and controls, respectively, indicating some significantly less residues in blood serum of control females. While PCBs residues detected were 54+/-17, 59+/-23 and 61+/-21ng/g, for the three groups, respectively. Residues of DDE detected in all females alike in the present study are about 15 times higher than residues detected in Canada and The Netherlands.