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. 2001 Dec;85(12):1426-8.
doi: 10.1136/bjo.85.12.1426.

Plasma malondialdehyde and nitric oxide levels in age related macular degeneration

Y Totan  1 , O Cekiç, M Borazan, E Uz, S Sögüt, O Akyol
Affiliations

Plasma malondialdehyde and nitric oxide levels in age related macular degeneration

Y Totan et al. Br J Ophthalmol. 2001 Dec.

Abstract

Aims: To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD).

Methods: Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects.

Results: Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively).

Conclusion: The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.

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Figures

Figure 1
Figure 1
Plot of plasma malondialdehyde (MDA) levels in patients with age related macular degeneration (ARMD) and control subjects.
Figure 2
Figure 2
Plot of plasma nitrite plus nitrate levels in patients with age related macular degeneration (ARMD) and control subjects.
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