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. 1975;36(Suppl 5):409-14.
doi: 10.1111/j.1600-0773.1975.tb00808.x.

Pharmacokinetics of cyclophosphamide in renal failure

Pharmacokinetics of cyclophosphamide in renal failure

H T Mouridsen et al. Acta Pharmacol Toxicol (Copenh). 1975.

Abstract

The metabolism of cyclophosphamide was determined in five patients with severe renal insufficiency. After the intravenous injection of 14-C-cyclophosphamide the activities due to unchanged cyclophosphamide and metabolites were determined in samples from urine and serum for 2-3 days. Only 22% of the injected radioactivity could be recovered in the urine during the first 3 days as against the normal of some 65% The rate of biotransformation seemed normal and in agreement with these findings a very long term retention of metabolites could be demonstrated. The clinical implications of these results are discussed.

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