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Review
. 2001 Oct;66(10):1174-86.
doi: 10.1023/a:1012445316415.

Structure and functions of classical cadherins

D B Ivanov  1 , M P Philippova, V A Tkachuk
Affiliations
Free article
Review

Structure and functions of classical cadherins

D B Ivanov et al. Biochemistry (Mosc). 2001 Oct.
Free article

Abstract

Cadherins are a family of membrane receptors that mediate calcium-dependent homophilic cell-cell adhesion. Cadherins play a key role in the regulation of organ and tissue development during embryogenesis. In adult organisms, these proteins are responsible for formation of stable cell-cell junctions and maintenance of normal tissue structure. Disruption in expression or function of cadherins may cause uncontrolled cell migration and proliferation during tumor development. This review focuses on the structure and physiological functions of classical cadherins.

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