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. 2002 Jan;4(1):66-72.
doi: 10.1038/ncb728.

The exocyst is a Ral effector complex

Serge Moskalenko  1 , Dale O Henry, Carine Rosse, Gladys Mirey, Jacques H Camonis, Michael A White
Affiliations

The exocyst is a Ral effector complex

Serge Moskalenko et al. Nat Cell Biol. 2002 Jan.

Abstract

Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for establishing and maintaining cell polarity, neurite differentiation and regulated exocytosis. The exocyst is a multisubunit complex required for vectorial targeting of a subset of secretory vesicles. Mechanisms that regulate the activity of this complex in mammals are unknown. Here we show that Sec5, an integral component of the exocyst, is a direct target for activated Ral GTPases. Ral GTPases regulate targeting of basolateral proteins in epithelial cells, secretagogue-dependent exocytosis in neuroendocrine cells and assembly of exocyst complexes. These observations define Ral GTPases as critical regulators of vesicle trafficking.

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