Comment
doi: 10.1016/s1534-5807(01)00095-8.
Neuralized: regulating notch by putting away delta
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- PMID: 11740931
- DOI: 10.1016/s1534-5807(01)00095-8
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Comment
Neuralized: regulating notch by putting away delta
Dev Cell.
2001 Dec.
Free article
Abstract
Neuralized acts in a subset of Notch-dependent cell fate decisions including lateral inhibition in Drosophila neurogenesis. Three recent papers reveal that Neuralized acts as a ubiquitin ligase and triggers endocytosis of the ligand Delta.
Comment on
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Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.Dev Cell. 2001 Dec;1(6):783-94. doi: 10.1016/s1534-5807(01)00092-2. Dev Cell. 2001. PMID: 11740940
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Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.Dev Cell. 2001 Dec;1(6):795-806. doi: 10.1016/s1534-5807(01)00091-0. Dev Cell. 2001. PMID: 11740941
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neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.Dev Cell. 2001 Dec;1(6):807-16. doi: 10.1016/s1534-5807(01)00093-4. Dev Cell. 2001. PMID: 11740942
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