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. 2001 Nov-Dec;215(6):415-8.
doi: 10.1159/000050900.

Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy

Y Mitamura  1 , S Takeuchi, A Matsuda, Y Tagawa, Y Mizue, J Nishihira
Affiliations

Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy

Y Mitamura et al. Ophthalmologica. 2001 Nov-Dec.

Abstract

Purpose: To investigate the correlation between monocyte chemotactic protein-1 (MCP-1) levels in the vitreous and clinical findings in eyes with proliferative diabetic retinopathy (PDR).

Methods: We assayed MCP-1 levels by ELISA in vitreous samples of 88 consecutive patients with PDR (52 eyes) and macular holes or idiopathic epimacular membrane (controls, 36 eyes).

Results: The level of MCP-1 in the vitreous was 2,097.5 +/- 1,099.4 pg/ml (mean +/- SD) in PDR, and 504.3 +/- 405.6 pg/ml in the controls. In PDR eyes, multivariate regression analysis revealed a significant association between MCP-1 levels in the vitreous and the degree of proliferative membrane, and a significant negative association between MCP-1 levels and the extent of preoperative retinal photocoagulation.

Conclusion: The results suggest that MCP-1 may play a role in the development of the proliferative phase of PDR.

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