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Review
. 2001 Dec 13;414(6865):792-8.
doi: 10.1038/414792a.

beta-Cell death during progression to diabetes

D Mathis  1 , L Vence, C Benoist
Affiliations
Review

beta-Cell death during progression to diabetes

D Mathis et al. Nature. .

Abstract

The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

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