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. 2002 Jan;30(1):25-6.
doi: 10.1038/ng799. Epub 2001 Dec 17.

Small changes in expression affect predisposition to tumorigenesis

Hai Yan  1 , Zuzana Dobbie, Stephen B Gruber, Sanford Markowitz, Kathy Romans, Francis M Giardiello, Kenneth W Kinzler, Bert Vogelstein
Affiliations

Small changes in expression affect predisposition to tumorigenesis

Hai Yan et al. Nat Genet. 2002 Jan.

Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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