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. 2001 Nov 1;92(9):2412-8.
doi: 10.1002/1097-0142(20011101)92:9<2412::aid-cncr1590>3.0.co;2-7.

Results of conservative treatment in epithelial ovarian carcinoma

P Morice  1 , F Wicart-Poque, A Rey, J El-Hassan, P Pautier, C Lhommé, R de Crevosier, C Haie-Meder, P Duvillard, D Castaigne
Affiliations

Results of conservative treatment in epithelial ovarian carcinoma

P Morice et al. Cancer. .

Abstract

Background: The objective of this study was to assess and evaluate the clinical outcome and fertility in patients treated conservatively for epithelial ovarian carcinoma (EOC).

Methods: Thirty-one patients treated with conservative management EOC were followed up. Optimal surgical staging was performed in 2 cases during the initial surgery and in 27 patients during a reassessment surgery. Six patients underwent hysterectomy during this restaging surgery.

Results: Among 25 patients treated conservatively after the restaging surgery, the International Federation of Gynecology and Obstetrics (FIGO) staging distribution was 19 Stage IA (Grade 1, n = 9; Grade 2, n = 10), 1 Stage IC, 2 Stage II, and 3 patients with initial stage unknown. Seven patients had recurrence (five on the remaining ovary). The disease free survival rate at 5 years for patients with Stage IA Grade 1 and 2 tumors were 89% and 71%, respectively. All patients with Stage IA or higher disease experienced recurrence. Only four pregnancies (three spontaneous and one after in vitro fertilization procedure) were obtained.

Conclusions: Conservative surgery for patients with EOC could be considered in young patients with Stage IA Grade 1 disease adequately staged and desiring to preserve fertility potential. This procedure should not performed in patients with disease staged higher than FIGO Stage IA.

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