doi: 10.1016/0005-2787(75)90035-0.
X-ray photoelectron spectroscopy of DNA-Pt complexes. Evidence of O6 (Gua)-N7 (Gua) chelation of DNA with cis- dichlorodiamine platinum(II)
- PMID: 1174534
- DOI: 10.1016/0005-2787(75)90035-0
Item in Clipboard
X-ray photoelectron spectroscopy of DNA-Pt complexes. Evidence of O6 (Gua)-N7 (Gua) chelation of DNA with cis- dichlorodiamine platinum(II)
Biochim Biophys Acta.
.
Abstract
The binding energies of nitrogen, oxygen, phosphorus, chlorine and Pt in several DNA - Pt (II) complexes are reported and discussed. The nitrogen band of DNA is slightly shifted upon complexation with Pt. Oxygen binding energies in the complexes studied clearly show that cis-Pt(NH3)2Cl2 forms a specific chelate N7(Gua) - O6 (Gua) with DNA as opposed to trans-Pt(NH3)2Cl2 and the other Pt compounds which react only with the N7(Gua) site of DNA.
Similar articles
-
DNA-platinum interactions in vitro with trans- and cis-Pt(NH3)2Cl2.Bioinorg Chem. 1975;5(1):59-66. doi: 10.1016/s0006-3061(00)80221-5. Bioinorg Chem. 1975. PMID: 1182209
-
Differentiation between chelated and non-chelated DNA-Pt complexes by atomic absorption spectrophotometry.Biochim Biophys Acta. 1976 Aug 18;442(2):142-6. doi: 10.1016/0005-2787(76)90484-6. Biochim Biophys Acta. 1976. PMID: 953006
-
Binding of the anticancer drug cis-dichlorodiammineplatinum to 3'(2')-guanosine monophosphate and nucleic acids.Anticancer Res. 1981;1(6):383-8. Anticancer Res. 1981. PMID: 6284018
-
The new antitumor compound, cis-[Pt(NH3)2(4-methylpyridine)Cl]Cl, does not form N7,N7-d(GpG) chelates with DNA. An unexpected preference for platinum binding at the 5'G in d(GpG).J Inorg Biochem. 1990 Sep;40(1):23-35. doi: 10.1016/0162-0134(90)80037-x. J Inorg Biochem. 1990. PMID: 2283508
-
Pt(II) complexes of unsubstituted guanine and 7-methylguanine.Dalton Trans. 2010 Jan 7;(1):73-84. doi: 10.1039/b912701a. Epub 2009 Oct 29. Dalton Trans. 2010. PMID: 20023936
Cited by
-
Sensitive Marker of the Cisplatin-DNA Interaction: X-Ray Photoelectron Spectroscopy of CL.Bioinorg Chem Appl. 2012;2012:649640. doi: 10.1155/2012/649640. Epub 2012 Oct 24. Bioinorg Chem Appl. 2012. PMID: 23133406 Free PMC article.
-
A strategy for the development of two clinically active cisplatin analogs: CBDCA and CHIP.Cancer Chemother Pharmacol. 1990;25(6):395-404. doi: 10.1007/BF00686049. Cancer Chemother Pharmacol. 1990. PMID: 2178792 Review.
-
Electron microscopical demonstration of nucleic acids in virus-like particles in the skeletal muscle of a traffic accident victim.Acta Neuropathol. 1979 Jun 15;47(1):55-9. doi: 10.1007/BF00698273. Acta Neuropathol. 1979. PMID: 463505
-
[Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)].Klin Wochenschr. 1979 Dec 3;57(23):1249-58. doi: 10.1007/BF01492980. Klin Wochenschr. 1979. PMID: 121143 Review. German.
-
Cis-dichloro-diammine platinum (II) as stain for electron microscopic preparations.Histochemistry. 1977 Mar 4;51(2-3):257-60. doi: 10.1007/BF00567230. Histochemistry. 1977. PMID: 66223
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
