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Comparative Study
. 2001 Dec;14(6):659-67.
doi: 10.1002/jmri.10021.

Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study

W Lin  1 , A Celik, C Derdeyn, H An, Y Lee, T Videen, L Ostergaard, W J Powers
Affiliations
Comparative Study

Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study

W Lin et al. J Magn Reson Imaging. 2001 Dec.

Abstract

Although it has been demonstrated that quantitative measures of cerebral blood flow (CBF) can be obtained with the singular value decomposition (SVD) algorithm, the extent to which quantitative CBF measurements can be utilized under pathophysiological conditions has not been systematically studied. A total of five healthy volunteers and five patients with unilateral carotid artery occlusion were studied. Only magnetic resonance (MR) images were acquired for the volunteer group while both MR and positron emission tomography (PET) images were acquired for the patient group. Assessments of CBF from normal volunteers compared favorably with values reported in the literature. However, while a linear relationship was observed for each patient when MR measured CBF was compared to that obtained from PET, this linear relationship diminished when all patients were analyzed as a group (r = 0.41). A correction factor (CF) was proposed that was equal to the ratio of the area of the venous output function (VOF) in each patient to the mean VOF obtained from the volunteer group. After globally scaling the CBF of each patient based on the experimentally derived CF, a substantial improvement was observed (a slope of 1.02 and r = 0.8 for the linear regression line) in the relationship between MR estimated CBF and those obtained from PET.

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Figures

Figure 1
Figure 1
The concentration time curves for both the AIF (a) and the VOF (b) obtained from the volunteer group. A substantial variability is observed in the AIF compared to the VOF.
Figure 2
Figure 2
CBF maps obtained from a healthy volunteer across five contiguous slices. Notice the high CBF values are associated with cortical vessels.
Figure 3
Figure 3
Representative T1- (a–c) and T2-weighted (d–e) images obtained from a patient with left internal carotid occlusion.
Figure 4
Figure 4
A comparison of the co-registered MR (a) and PET (b) CBF maps is shown.
Figure 5
Figure 5
Relationship between MR measured CBF and that obtained from PET for each patient is shown. Despite the observed linear relationship in each individual patient, the slopes of the linear regression lines vary between patients.
Figure 6
Figure 6
Relationships between MR estimated CBF and that obtained from PET are shown without (a) and with the proposed correction algorithm (b).
See this image and copyright information in PMC

References

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