Review
doi: 10.1016/s0960-9822(01)00620-0.
Molecular chaperones: inside and outside the Anfinsen cage
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- PMID: 11747844
- DOI: 10.1016/s0960-9822(01)00620-0
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Review
Molecular chaperones: inside and outside the Anfinsen cage
Curr Biol.
.
Free article
Abstract
The GroEL/GroES chaperonin system acts as a passive anti-aggregation cage for refolding rubisco and rhodanese, and not as an active unfolding device. Refolding aconitase is too large to enter the cage but reversible binding to GroEL reduces its aggregration. Unexpectedly, confinement in the cage increases the rate of refolding of rubisco, but not rhodanese.
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