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Comment

. 2001 Dec;108(12):1741-2.

doi: 10.1172/JCI14651.

Turning on LIGHT

S W Granger¹, C F Ware

Affiliations

PMID: 11748255
PMCID: PMC209475
DOI: 10.1172/JCI14651

Comment

Turning on LIGHT

S W Granger et al. J Clin Invest. 2001 Dec.

. 2001 Dec;108(12):1741-2.

doi: 10.1172/JCI14651.

Authors

S W Granger¹, C F Ware

Affiliation

¹ Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.

PMID: 11748255
PMCID: PMC209475
DOI: 10.1172/JCI14651

No abstract available

PubMed Disclaimer

Figures

Figure 1
Organization of the TNF superfamily genes within the paralogous regions present on chromosomes 1, 6, and 19. Left panel: Diagram of the human chromosome 19p13.3 region containing the LIGHT genomic locus. Middle panel: Distribution of TNF paralogous superfamily gene clusters arranged from centromere to telomere. Arrows indicate gene transcriptional orientation, and solid blocks represent exons. LIGHT is 7.78 kb from C3 and about 79 kb from CD27L. CD27L is about 235 kb from 4-1BBL. FasL is separated from AITRL by 374 kb, while AITRL and OX40L are 134 kb apart. TNF is 2.9 kb from LTβ and 1.3 kb from LTα. Right panel: activities of the TNF-related ligands on T cells.

See this image and copyright information in PMC

Comment on

The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.
Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX. Wang J, et al. J Clin Invest. 2001 Dec;108(12):1771-80. doi: 10.1172/JCI13827. J Clin Invest. 2001. PMID: 11748260 Free PMC article.

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References

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1. Wang J, et al. The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT. J Clin Invest. 2001;108:1771–1780. - PMC - PubMed
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1. Yu KY, et al. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 1999;274:13733–13736. - PubMed

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