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Comment
. 2001 Dec;108(12):1741-2.
doi: 10.1172/JCI14651.

Turning on LIGHT

S W Granger  1 , C F Ware
Affiliations
Comment

Turning on LIGHT

S W Granger et al. J Clin Invest. 2001 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Organization of the TNF superfamily genes within the paralogous regions present on chromosomes 1, 6, and 19. Left panel: Diagram of the human chromosome 19p13.3 region containing the LIGHT genomic locus. Middle panel: Distribution of TNF paralogous superfamily gene clusters arranged from centromere to telomere. Arrows indicate gene transcriptional orientation, and solid blocks represent exons. LIGHT is 7.78 kb from C3 and about 79 kb from CD27L. CD27L is about 235 kb from 4-1BBL. FasL is separated from AITRL by 374 kb, while AITRL and OX40L are 134 kb apart. TNF is 2.9 kb from LTβ and 1.3 kb from LTα. Right panel: activities of the TNF-related ligands on T cells.
See this image and copyright information in PMC

Comment on

References

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    1. Wang J, et al. The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT. J Clin Invest. 2001;108:1771–1780. - PMC - PubMed
    1. Shaikh R, et al. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction. J Immunol. 2001;167:6330–6337. - PubMed
    1. Mauri DN, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity. 1998;8:21–30. - PubMed
    1. Yu KY, et al. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 1999;274:13733–13736. - PubMed

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