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. 1979 Nov;65(3):247-50.
doi: 10.1007/BF00492211.

Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats

M M Bernardi, J P Neto

Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats

M M Bernardi et al. Psychopharmacology (Berl). 1979 Nov.

Abstract

The effects of abrupt and gradual withdrawal from long-term haloperidol treatment on rat open field behavior was studied. Abrupt withdrawal induced a significant increase in all parameters of activity observed except defecation, this increase being higher 72 h after the last haloperidol injection. Results were considered to be a consequence of supersensitivity of central dopaminergic receptors. These differences were almost unobservable in animals gradually withdrawn, thus suggesting that the phenomenon is reversible.

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