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. 2001 Dec;54 Suppl 1(Suppl 1):S3-8.
doi: 10.1016/s0895-4356(01)00440-1.

Justification for a new cohort study of people aging with and without HIV infection

A C Justice  1 , C S Landefeld, S M Asch, A L Gifford, C C Whalen, K E Covinsky
Affiliations

Justification for a new cohort study of people aging with and without HIV infection

A C Justice et al. J Clin Epidemiol. 2001 Dec.

Abstract

This supplement contains a series of papers supporting the justification, design, and implementation of a longitudinal cohort study of an aging HIV-positive and HIV-negative veteran population called the Veterans Aging Cohort Study (VACS). Although the papers cover a wide range of topics and several papers address methodologic issues not unique to a study of aging veterans, all are motivated by a unifying set of assumptions. Specifically: (a) HIV/AIDS is a chronic disease in an aging population; (b) conditions among HIV-positive and -negative patients in care have overlapping etiologies; (c) individuals with pre-existing organ injury are at increased risk for iatrogenic injury; (d) cohort studies are uniquely suited to the study of chronic disease complicated by aging, comorbid conditions, drug toxicities, and substance use/abuse; (e) VACS is well positioned to study HIV as a chronic disease in an aging population.

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Figures

Fig. 1
Fig. 1
Etiology of “non-HIV-related” comorbidity.
See this image and copyright information in PMC

References

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    1. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action on SEroConversion to AIDS and Death in Europe. Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antitretroviral therapy: a collaborate re-analysis. Lancet. 2000;355:1131–7. - PubMed
    1. Justice AC, Weissman S. The survival experience of older and younger adults with AIDS: is there a growing gap in survival? Res Aging. 1998;20:665–85.
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    1. Justice AC, Feinstein AR, Wells CK. A new prognostic staging system for the acquired immunodeficiency syndrome. N Engl J Med. 1989;320:1388–93. - PubMed

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