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Comparative Study
. 1979 Nov;65(3):311-5.
doi: 10.1007/BF00492220.

Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat

R Pechnick, D S Janowsky, L Judd
Comparative Study

Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat

R Pechnick et al. Psychopharmacology (Berl). 1979 Nov.

Abstract

Different equimolar doses of d-amphetamine and methylphenidate were compared for their potency in eliciting stereotyped behavior in rats. Although at lower doses d-amphetamine appeared more effective in causing stereotyped gnawing, repetitive body movements, and sniffing, at higher doses methylphenidate at certain times caused a greater incidence of gnawing than did d-amphetamine. Understanding these differences and comparing related biochemical correlates may lead to a better definition of mechanisms underlying psychostimulant effects.

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