A randomised trial of progesterone prophylaxis after midtrimester amniocentesis

Abstract

Background: Midtrimester amniocentesis to investigate fetal karyotype carries a small risk of fetal loss.

Aim: To test the hypothesis that progesterone prophylaxis may reduce this.

Study design: A randomised controlled trial comparing a short prophylactic treatment with progesterone after amniocentesis with untreated controls.

Results: There were no differences in frequency of miscarriage, preterm delivery or neonatal outcome.

Conclusion: Prophylactic progesterone treatment after amniocentesis does not improve obstetric outcome.