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Comparative Study
. 2002 Jan;46(1):220-4.
doi: 10.1128/AAC.46.1.220-224.2002.

In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds

Dianne B Hoellman  1 , Linda M Kelly, Kim Credito, Lauren Anthony, Lois M Ednie, Michael R Jacobs, Peter C Appelbaum
Affiliations
Comparative Study

In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds

Dianne B Hoellman et al. Antimicrob Agents Chemother. 2002 Jan.

Abstract

Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active beta-lactams (MICs at which 50% of the strains are inhibited [MIC(50)s], 0.125 to 0.25 microg/ml; MIC(90)s, 1.0 to 2.0 microg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other beta-lactams were similar to those of ertapenem.

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References

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